During the past few years, modeling tools for antibody discovery and engineering have been developed, taking advantage of the structural knowledge existing in the protein database (PDB).
At Roche, a modeling tool is automatically producing high quality models at a very low computational cost. The tool uses an antibody structural database dissected in heavy and light chains, frameworks, and Complement Determining Regions (CDRs) segments that enables novel features in searching templates during modeling. An accurate prediction of the relative VH-VL orientation ensures the model quality. The VH-VL orientation prediction is also used to predict the CDR grafting success during humanization.
Watch this webinar to learn how to automate the generation of high-quality antibody structure models.
Guy Georges, Roche and Hugues-Olivier Bertrand, Dassault Systèmes BIOVIA
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Accurate Antibody Molecular Modeling Enables Epitope Determination
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